Salk researchers and collaborators show how the protein damages cells, confirming COVID-19 as a primarily vascular disease
LA JOLLA—Scientists have known for a while that SARS-CoV-2’s distinctive “spike” proteins help the virus infect its host by latching on to healthy cells. Now, a major new study shows that the virus spike proteins (which behave very differently than those safely encoded by vaccines) also play a key role in the disease itself.
The paper, published on April 30, 2021, in Circulation Research, also shows conclusively that COVID-19 is a vascular disease, demonstrating exactly how the SARS-CoV-2 virus damages and attacks the vascular system on a cellular level. The findings help explain COVID-19’s wide variety of seemingly unconnected complications, and could open the door for new research into more effective therapies.
“A lot of people think of it as a respiratory disease, but it’s really a vascular disease,” says Assistant Research Professor Uri Manor, who is co-senior author of the study. “That could explain why some people have strokes, and why some people have issues in other parts of the body. The commonality between them is that they all have vascular underpinnings.”
Salk researchers collaborated with scientists at the University of California San Diego on the paper, including co-first author Jiao Zhang and co-senior author John Shyy, among others.
While the findings themselves aren’t entirely a surprise, the paper provides clear confirmation and a detailed explanation of the mechanism through which the protein damages vascular cells for the first time. There’s been a growing consensus that SARS-CoV-2 affects the vascular system, but exactly how it did so was not understood. Similarly, scientists studying other coronaviruses have long suspected that the spike protein contributed to damaging vascular endothelial cells, but this is the first time the process has been documented.
In the new study, the researchers created a “pseudovirus” that was surrounded by SARS-CoV-2 classic crown of spike proteins, but did not contain any actual virus. Exposure to this pseudovirus resulted in damage to the lungs and arteries of an animal model—proving that the spike protein alone was enough to cause disease. Tissue samples showed inflammation in endothelial cells lining the pulmonary artery walls.
The team then replicated this process in the lab, exposing healthy endothelial cells (which line arteries) to the spike protein. They showed that the spike protein damaged the cells by binding ACE2. This binding disrupted ACE2’s molecular signaling to mitochondria (organelles that generate energy for cells), causing the mitochondria to become damaged and fragmented.
Previous studies have shown a similar effect when cells were exposed to the SARS-CoV-2 virus, but this is the first study to show that the damage occurs when cells are exposed to the spike protein on its own.
“If you remove the replicating capabilities of the virus, it still has a major damaging effect on the vascular cells, simply by virtue of its ability to bind to this ACE2 receptor, the S protein receptor, now famous thanks to COVID,” Manor explains. “Further studies with mutant spike proteins will also provide new insight towards the infectivity and severity of mutant SARS CoV-2 viruses.”
The researchers next hope to take a closer look at the mechanism by which the disrupted ACE2 protein damages mitochondria and causes them to change shape.
Other authors on the study are Yuyang Lei and Zu-Yi Yuan of Jiaotong University in Xi’an, China; Cara R. Schiavon, Leonardo Andrade, and Gerald S. Shadel of Salk; Ming He, Hui Shen, Yichi Zhang, Yoshitake Cho, Mark Hepokoski, Jason X.-J. Yuan, Atul Malhotra, Jin Zhang of the University of California San Diego; Lili Chen, Qian Yin, Ting Lei, Hongliang Wang and Shengpeng Wang of Xi’an Jiatong University Health Science Center in Xi’an, China.
The research was supported by the National Institutes of Health, the National Natural Science Foundation of China, the Shaanxi Natural Science Fund, the National Key Research and Development Program, the First Affiliated Hospital of Xi’an Jiaotong University; and Xi’an Jiaotong University.
Protecting yourself from the spike protein contagion
All along I have assumed that there is some such antidote, with which Fauci/Gates
and all their masters and familiars “stay safe” while their pathogens kill off the rest
of us; and here, apparently, it is.
Possible Antidote for the V-Serum and the Current Spike Protein Contagion
Dr. Judy Mikovits (1 min. MP4 is attached) has revealed that the medical establishment has known all along about the antidote to the contagion – acontagion that is now being seen today by thousands of people who have not taken the serum, but have merely come in close proximity with others who have taken the jab.
(The word “serum” is being used here since, evidently, the way to avoid taking the jab is to say “I am allergic to the serum”.)
When the medical establishment and political promoters want to exempt themselves from taking inoculations, they always give themselves a legal way out, while pushing the “citizenry” to take the jabs.
“I am allergic to the serum” is one of their solutions.
Taking the serum is one thing. The spike protein contagion now being experienced in large numbers by those who did not take the serum, but just visited with a relative or friend who did, is entirely new and unprecedented.
What are the side effects being seen by this contagion?
- massive headaches
- micro-clots and sudden bruising throughout the body
- exceptionally heavy menstrual cycles among both the young and post menopausal
- reduction in breast milk
- sterility among both women and men
- household pets dying shortly after the owners get the serum.
Listen to 5 doctors discuss this unusual onset of symptoms being experienced now by thousands:
URGENT! 5 Doctors Agree that COVID-19 Injections are Bioweapons and Discuss What to do About It
The Antidote to the Contagion
This antidote to the contagion, that has been known of by the upper levels of the medical establishment and insiders of the elitist class for almost 100 years, is called Suramin, an isolated compound originally derived from an extract of pine needle oil.
It is only available by injection, and has been a closely guarded secret not made openly available to the masses during this “pandemic”, yet is an effective solution for parasites and viruses of several kinds, along with a large number of other conditions.
Yet anyone can now take advantage of this solution by tapping its root origin, pine needle tea, an antidote that is freely available today in evergreen forests and in many people’s backyards. (Sources for buying it are also listed below.)
How can this simple remedy work so well in the face of such a seemingly insurmountable condition?
There is a direct relationship between Suramin (the isolated extract), pine needle tea (a hot water extract of the pine, fir, cedar, and spruce needles), and pine oil (which is derived from the needles though an essential oil steam distillation process).
All three are derived from the properties of the conifer needle.
My personal take on this is that it is far better to get Nature’s whole herb source than just a tiny fraction of an extract. There are many other benefits that can be derived from the whole herb that will be missing from the isolated chemical.
My observation is that those who maintain high levels of health are not affected by either the serum nor the transference contagion. Their immune system seems to be warding off side effects at this point. Come winter when the spike protein in their bodies will be challenged with new pathogens, we will all discover our true levels of health.
Anyone on the fence health-wise, or depleted (which can be said of many of us today), are being affected to varying degrees.
The Trail from Suramin to Pine Needle Tea
Here is the trail of science and data that shows the derivative relationship between pine needles and Suramin (“the elist’s antidote” to microbial illnesses) – and which also provides a potential antidote for those affected by the spike protein contagion (for reasons explained within the following data):
Suramin is used for treatment of human sleeping sickness caused by trypanosomes. [a parasite] Specifically, it is used for treatment of first-stage African trypanosomiasis caused by Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense without involvement of central nervous system. It is considered first-line treatment for Trypanosoma brucei rhodesiense, and second-line treatment for early-stage Trypanosoma brucei gambiense, where pentamidine is recommended as first line.
Suramin has been available to the medical profession for almost 100 years. A summary of its antioxidant benefits are outlined in this report – 100 Years of Suramin (attached as a PDF).
The most relevant parts of the summary are outlined below with supportive evidence:
SURAMIN, THE FRUIT OF EARLY MEDICINAL CHEMISTRY
When suramin was introduced for the treatment of African sleeping sickness in 1922, it was one of the first anti-infective agents that had been developed in a medicinal chemistry program. Starting from the antitrypanosomal activity of the dye trypan blue, synthesized in 1904 by Paul Ehrlich, Bayer made a series of colorless and more potent derivatives. Molecule 205 was suramin (Fig. 1), synthesized by Oskar Dressel, Richard Kothe, and Bernhard Heymann in 1916. Sleeping sickness (also known as human African trypanosomiasis [HAT]) was at the forefront of research at that time, not a neglected disease as it is today, and the development of suramin was a breakthrough for the emerging field of chemotherapy.
Now read the following paragraph within the subtitle (Too) Many Targets in the 100 Years of Suramin PDF to understand its antidote properties to the spike protein contagion (derived from the mRNA that gives instructions to replicate a spike protein in other cells):
Suramin further decreases the activities of a large number of enzymes involved in DNA and RNA synthesis and modification: DNA polymerases (103, 104), RNA polymerases (103, 105, 106), reverse transcriptase (18, 103), telomerase (67), and enzymes involved in winding/ unwinding of DNA (107, 108) are inhibited by suramin, as well as histone- and chromatin-modifying enzymes like chromobox proteins (109), methyltransferases (110), and sirtuin histone deacetylases (111)
This is medical-speak for inhibiting the inappropriate replication and modification of RNA and DNA.
This comment in the PDF also reveals Suramin’s ability to inhibit micro-clots:
Suramin also showed inhibitory effects against components of the coagulation cascade (71, 130)…
Excessive coagulation causes blood clots, mini-clots, strokes, and unusually heavy menstrual cycles.
This is why so many people are dying today of blood clots after receiving the serum, and why others are now showing unexplained bruising after coming in contact with one that has taken the serum.
Something is being transferred from one to the other, likely through the breath, complemented by a type of sympathetic resonance, or pheromone emanation.
The method of transfer is unclear at this point, but is certainly happening.
This phenomenon is not an accident, these symptoms were known well in advance of unleashing this serum on the public. Vaccine trials have been going on for decades.
Why did they decide to test a completely new approach with the mRNA without animal trials, thus using humans as the first test case for their effectiveness?
An Obvious Sham
Any natural medicine with 0.01% of these deaths and side effects would have been pulled from the market immediately. That our professionals and decision-makers have continued to allow this sham to continue reveals that this sham is intentional.
The upper echelon of the medical profession promote this program to the people, while they exempt themselves from it, and then take their personal antidote to prevent being affected by the transference contagion.
Since when is it acceptable to kill thousands of people and maim hundreds of thousands more with a “medicine”??? Why are we finding this OK? Why are we still trusting the media and the medical wizards that dreamed up this sham? When will enough be enough?
The People’s Antidote
Now the people have the antidote, and it is readily available in the form of pine needle tea. How do we know this? Because Suramin is a derivative of the oils in pine needles.
The whole herbal source (needles) is superior to the single compound extract (Suramin) – because the needles possess a full complement of phytonutrients providing numerous additional benefits that the extract is incapable of.
Now, here is the direct connection between Suramin and Pine Needle Tea:
Suramin is Derived from Trypan Blue
Trypan blue is derived from toluidine, that is, any of several isomeric bases, C14H16N2, derived from toluene. Trypan blue is so-called because it can kill trypanosomes, the parasites that cause sleeping sickness. An analog of trypan blue, suramin, is used pharmacologically against trypanosomiasis. Trypan blue is also known as diamine blue and Niagara blue…
Trypan red and trypan blue were first synthesized by the German scientist Paul Ehrlich in 1904.
Trypan Blue is a derivative of toluene which is a derivative of pine oil.
I personally recall many years ago one health professional was using a Pine Sol bath to rid the body of parasites.
Pine-Sol was based on pine oil when it was created in 1929 and during its rise to national popularity in the 1950s. However, as of 2016, Pine-Sol products sold in stores no longer contain pine oil to reduce costs.
Yet pine needle tea provides a similar, if not superior, benefit, due in part to the fact that it is a direct mild extract of the whole herb leaving many of its properties still intact that might be destroyed by excessive heat during distillation and further dissection of its many nutrient components.
I harvested some young Dougles Fir needles last fall and have been adding it to my morning tea blend for the last couple of months. It must have been an instinctive call. I discovered the Suramin info just last week.
The Douglas fir needle tea I have been drinking provides an energetic lift and a nice boost to the immune system.
Pine needles are high in vitamin C and A among numerous other compounds which provide a long list of benefits:
A 2011 Korean study demonstrated using pine needles in tea was the best way to access the antioxidant benefits from pine needles.
The study demonstrated that the hot water extract of pine needle proanthocyanidins and catechins offer the highest levels of antioxidant benefits compared with chemical extract processes.
There are other known benefits that pine needle tea and the tea made from other conifers share, which include:
- Improves circulation
- Relieves nervous exhaustion and fatigue
- Relieves sore muscles
Herbalists the world over have known all along about the benefits of this simple natural tea. Pine needle tea has been used medicinally worldwide for thousands of years.
Pine Needle Tea Video (3 min)
Wild Food Foraging – Pine / Spruce / Cedar / Fir – Evergreen Teas
A few notes of caution:
Be careful with the yew pine (which is not a true pine) and can be toxic, although it does have a few medicinal properties).
The cypress is not to be used as an essential oil in high doses, but normally safe otherwise.
The ponderosa pine is not good for cows mostly due to the observation when pregnant cattle eat the needles the loss of the calf has been observed, but has a long history of health benefits for humans for respiratory conditions, cuts, wounds, and burns, etc.
By far the vast majority of conifers have been used medicinally for thousands of years with an excellent track record. Get to know your trees. They may provide a medicine cabinet full of health benefits to you and your family.
Pine, spruce, cedar, and fir needle tea may end up being the easiest way to gain the numerous benefits of the evergreen trees, along with a natural protection against unhealthy replications of spike proteins today.
Combine with other herbs as desired to obtain further benefits and flavors.
Sources for Pine Needles
There is one primary American supplier (Etsy) for the pine needles (besides harvesting your own) that I am aware of at this point with 3 quality listings, each from a different East Coast wildcrafter:
Here is the main reference link for new wildcrafters when they post their harvests:
Dosage: 3 cups per day or more of any desired strength (based on the quantity of needles added to a french press or teapot) with an approximate 1-3 tablespoons of needles per cup of near boiling water. This is a maintenance health-building dose.
Stronger amounts of needles to water can be used therapeutically. If it feels too acidic (due to the vitamin C) for your system, moderate the quantity and complement the tea with alkalizing food and dark green herbs or sea vegetables.
— — —
In order to grasp the seriousness of the situation we are in, and to understand why, we need to look back in history to the times in which this very day had been forecast, obviously planned for, and now created.
Here is one clear example:
“Jacques Attali was an advisor to François Mitterrand (former President of France) and wrote this in 1981:
“In the future it will be a question of finding a way to reduce the population. We will start with the old man, because once he is over 60-65 years old, man lives longer than he produces and it costs society dearly.
Then the weak and then the useless who do not contribute anything to society because there will be more and more, and especially finally the stupid.
Euthanasia directed at these groups; euthanasia must be an essential instrument of our future societies, in all cases.
Of course, we will not be able to execute people or organize camps. We will get rid of them by making them believe that it is for their own good.
Too large a population, and for the most part unnecessary, is something economically too expensive. Socially, it is also much better for the human machine to stop abruptly rather than gradually deteriorate.
We won’t be able to pass intelligence tests on millions and millions of people, you can imagine!
We will find something or cause it; a pandemic that targets certain people, a real economic crisis or not, a virus that will affect the old or the elderly, it does not matter, the weak and the fearful will succumb.
The stupid will believe it and ask to be treated. We will have taken care of having planned the treatment, a treatment that will be the solution.
The selection of idiots will therefore be done by itself: they will go to the slaughterhouse alone. “ This fragment is excerpted from his book “Brief History of the Future”, published in France in 2006.”
Understand that we are smart enough to find our own solutions, and apply them. Those willing to take proactive protective measures, maintain their health, and become more self-reliant will rise from this period of change and transformation successfully.
We will be the ones to structure the world to come with a new focus on the common good of all life everywhere. The old mindset expressed by that limited soul above will not be tolerated. That mindset, and those that harbor it, will vanish like the darkness before the approaching dawn.
It is true that many will go with the passing night, yet those that remain will then shine all the brighter.
Do your part. Take care of yourself first, then look to assist any willing to listen and join in the reconstruction.